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Epigenetic alterations Cancer initiation and progression are caused not solely by UV-induced mutations in significant genes but also by the subsequent alterations in epigenetics, which result in their abnormal expression patterns conducive to cancer development and aggressive behavior

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The IC 50 of approximately 1000 mol/L for WT MEFs was significantly reduced to 100 mol/L in Zmpste24 -deficient MEFs (Fig

Maintenance of ROS homeostasis and ROS generation regulates seed germination through GA and/or ABA metabolism and signalling in Arabidopsis and barley, respectively [61, 62]

These beneficial effects were abolished when inhibition was performed by using Nrf2-siRNA