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At the same time, mTORC1 in active state inhibits autophagy by suppressing activity of the Unc-51-like kinase 1 (ULK1) and initiates protein biosynthesis via phosphorylation of the main mRNA translation regulators, such as proteins of the 4E-BP group inhibiting protein synthesis initiation factor eIF4E [27]

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123,124 The recent phenomenon has therapeutic implications related to asthma by preventing proliferation and remodeling of smooth muscle cells