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doi: 10.1016/j.amjms.2019.09.002 128 PapadopoulosPDTsigalouCValsamakiPNKonstantinidisTGVoidarouCBezirtzoglouE

Anethole, a Medicinal Plant Compound, Decreases the Production of Pro-Inflammatory TNF- and IL-1 in a Rat Model of LPS-Induced Periodontitis

In one, multi-clinic, placebo-controlled study employing an add-on design (adjunctive therapy), 144 patients who continued to suffer eight or more CPS per 8 weeks during an 8 week period of monotherapy with doses of either carbamazepine or phenytoin sufficient to assure plasma concentrations within the "therapeutic range" were randomized to receive, in addition to their original antiepilepsy drug (AED), either divalproex sodium or placebo