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Regarding the modulation of intracellular zinc levels, cells overexpressing zinc importers, such as SLC39A4 , SLC39A6 , and SLC39A10 , were significantly enriched, whereas the overexpression of the zinc exporters SLC30A4 and SLC30A1 led to depletion from the cell pool

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For example, in the male reproductive system, melatonin can inhibit the expression of key steroidogenic genes (such as p450scc, p450c17, and StAR) in Leydig cells via MT1 receptors, thereby reducing testosterone synthesis (66) to inhibit sexual maturation, spontaneous ovulation, and the estrous response (67)

This study found hypozincemia in obese women due to elevated cortisol levels, which promote the production of metallothionein and ZIP-14 genes