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Inclusion criteria for all participants included the availability of CSF, PET, CT, or MRI data

The study showed that a genetic predisposition to elevated serum UA levels significantly increased the risk of CAD [OR =1.227 (95% CI: 1.1071.360)], arterial hypertension (OR =1.318), myocardial infarction (OR =1.184), HF (OR =1.158), angina (OR =1.150) and coronary heart disease (OR =1.170)

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This might partially explain the decreased renin in the POTS paradox

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