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During a month-long interruption, several physiological changes occur as the drug's effects dissipate

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Also, in the Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND) study, approximately 10 thousand patients with type 2 diabetes and history of CVD or cardiovascular risk factors were randomized to a weekly subcutaneous injection of dulaglutide 1.5 mg or placebo [16]

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Even so, when studies are reviewed it is important to qualify that effects may be limited to specific populations and that safety and indications should be assessed individually