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Importantly, GLP-1 agonists also have been shown to have protective effects in the brain

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The end product, GSH, exhibits negative feedback inhibition of -glutamylsynthetase to prevent the overproduction of GSH

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Xanthine oxidase, NAD(P)H oxidases, and cytochrome P450 catalyze enzymatic processes in the heart that produce reactive oxygen species during normal mitochondrial cellular functions during oxidative phosphorylation (Kele et al