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A direct head-to-head clinical trial comparing retatrutide to tirzepatide is currently being conducted by Eli Lilly, which will give us more definitive answers

Effectiveness Comparison Fat Loss: Tesamorelin excels at targeting visceral fat, making it ideal for those with significant fat reduction goals

In a 48-week clinical trial, higher doses consistently led to greater average weight loss: Weight loss by dose (48-week clinical trial) In this trial, at the highest dose (12 mg), people lost an average 24% of their starting weight on average

Ipamorelin supports fat loss by increasing growth hormone levels, which can help your body use fat for energy

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Interestingly, however, the participants who were also obese did show a significant reduction in heavy drinking days and total alcohol consumption