The rewiring of Gln metabolism may also contribute to the maladaptive cardiac remodeling response in PAH, as increases in glutaminolysis have been detected in the right ventricle of both monocrotaline-treated rats and human PAH patients [82]
Previous research on DGAT1 -/- mice demonstrated that DGAT1 was required for hepatic steatosis caused by a high-fat diet or fasting, both of which promote hepatic uptake of exogenous FAs, but not for hepatic steatosis caused by upregulation of endogenous de novo FA synthesis 65
The GCL from Trypanosoma brucei and the mammalian catalytic subunit share 45% amino acid identity, but the T
By combining these mechanisms, researchers can evaluate how coordinated receptor signaling influences metabolic function compared with single- or dual-receptor agonists [4]
Expression of kisspeptin/kiss1r system in developing hypothalamus of female rat and the possible effects on reproduction development and maintenance
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