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Patient instructions and counseling Take first dose of no more than 1 mg of any agent, and take at bedtime

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40 Addittionally, homocysteine has several procoagulant properties including the decrease of antithrombin III binding to endothelial heparan sulfate, increase of affinity between lipoprotein(a) and fibrin, induction of tissue factor activity in endothelial cells, and inhibition of inactivation of factor V by activated protein C

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It appears to do this through several mechanisms including upregulation of growth factors involved in mucosal repair, reduction of inflammatory mediators, and support of gut barrier integrity

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