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Causality of small and large intestinal microbiota in weight regulation and insulin resistance

LPL is synthesized as an inactive monomer in parenchymal cells and, with the support of specific endoplasmic reticulum chaperones (i.e., lipase maturation factor 1 and Sel-1 suppressor of lin-12- like protein), a noncovalent, active LPL dimer is formed, although both active and inactive forms of LPL are secreted [54]

However, during sepsis and muscle atrophy, IGF-1 levels in the muscle decline, which reduces protein synthesis (81-83)

doi: 10.1210/endo-117-3-824 34 HolzGKhtreiberWMHabenerJF

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