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PCR data showed that 200 M H 2 O 2 treatment upregulated IL-1, MMP13, Collagen-X, Caspase3, and Caspase9 at mRNA level in chondrocytes, while metformin significantly attenuated these H 2 O 2 exposure induced increases (Fig

In the early stage of OA, the subchondral bone exhibits increased remodeling activity, characterized by elevated bone turnover, microstructural deterioration, and a shift from bone resorption to formation

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