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It accumulates as unmetabolized folic acid (UMFA) and competes with active folates for receptors. Conversion between the two active forms is unreliable : it requires multiple enzymes (MTR, MTRR, SHMT, MTHFR, MTHFS) all working properly, and is easily blocked by low glutathione, B12 deficiency, heavy metals, or oxidative stress

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13 Furthermore, NACA decreased severity of selenite-induced cataract in rat pups

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These mechanisms include changes in microbial composition, immune activation, vagus nerve signaling, and the production of specific microbial neuroactive metabolites (197)