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The synthesis of GLP-1 in other areas of the brain plays a vital role in providing neuroprotection and suppressing neuroinflammation through the activation of GLP-1R

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Rose BA, Force T, Wang Y: Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale

Of particular interest is its active compound DNJ (1-deoxynojirimycin), a natural inhibitor of the alpha-glucosidase enzyme

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In conclusion, tirzepatide increased blood pressure and sympathetic activity in hypertensive rats without cardiac protection, highlighting context-dependent cardiovascular actions