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Given the significant unmet need in obesity management and the weight loss outcomes observed in early trials, there is considerable clinical interest though formal NICE appraisal remains some years away

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It is also noted that the 2016 List specifically mentions GW-1516, a substance developed to burn fat whilst exercising, but withdrawn from development after Glaxosmithkline found that it caused cancer in rodents

Clinical testing is appropriate for documented medical indications

10.1021/bi992887l 33 CraigS

Glutathione reductase (GR), which catalyzes the reaction NADPH + GSSG + H+ NADP+ + 2GSH, plays an important role in the maintenance of cellular oxidant status (15)