Constipation tends to be more persistent than diarrhea with both medications
My suspicion is that most people regain the weight because the treatment was short-term, focused on weight loss rather than developing better habits, and resulted in loss of muscle, which reduces your basal metabolic rate and makes you more likely to gain weight
[2] Willoughby, D., Hewlings, S., & Kalman, D
This guide covers how semaglutide dosing for weight loss works from the first injection through the maintenance phase, including the 2026 dosing changes, a unit-based chart for compounded versions, and the clinical reasoning behind why doses increase gradually over time
With respect to semaglutide: There is no USP or NF monograph for semaglutide
Some patients report that taking their GLP-1 medication before bed allows them to sleep through the period when side effects might be most noticeable, waking with reduced symptoms