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The durability of weight loss effects has been examined in the SURMOUNT-4 trial (Rubino et al., JAMA 2023), which demonstrated that discontinuation of tirzepatide after successful weight loss led to significant weight regain, suggesting ongoing treatment may be necessary for sustained benefits

Collectively, these findings underscore that SCD1 functions as a pivotal regulator of lipid metabolism and as a multifaceted modulator of cell death, energy homeostasis, and tissue-specific metabolic regulation [85]

-Cell signalling and insulin secretagogues: a path for improved diabetes therapy

As an adjunct to diet and exercise, Mounjaro (tirzepatide) improves glycemic control in adults with type 2 diabetes

This represents a significant patient safety concern that should not be underestimated

This is the foundation of an effective Zepbound meal plan