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Imaging was unremarkable, but after an episode of hematochezia, a colonoscopy was performed, which grossly showed signs of colonic ischemia with biopsied tissue demonstrating changes consistent with ischemic mucosa

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Quick Answer: Tirzepatide can be administered at any time of day, morning or night, as its pharmacokinetic profile maintains stable therapeutic levels with once-weekly dosing regardless of injection time

Rotating injection sites between abdomen, thigh, and upper arm prevents lipohypertrophy and maintains consistent absorption