However, this regulatory threshold does not define the only pathway to semaglutide therapy
Common signs of NAION include: Sudden, unilateral painless loss of vision Visual field defect (usually altitudinal) Blurred vision Dyschromatopsia (new onset impairment or loss of color vision) Relative afferent pupillary defect Optic disc swelling with or without hemorrhages A patient starting a GLP-1RAespecially if they have diabetes or age-related macular degeneration should have an in-person, comprehensive, dilated eye examination either within the 12 months prior to starting therapy or a baseline examination within one month of initiating therapy
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Some patients may experience symptoms that superficially resemble POTSsuch as dizziness, palpitations, or lightheadednesswhich are actually related to volume depletion, medication side effects, or rapid weight loss rather than true autonomic dysfunction
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MOTS-c has the most direct disc-specific evidence, with rat studies showing preserved disc height and reduced degeneration scores