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The upregulation of GDF15, a protein that plays a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes [4850], and EGR1, which encodes a transcriptional regulator that activates genes (including p53) required for differentiation and mitogenesis [51], was maintained closer to normal levels in cells pretreated with L-NAC, but not NAC (Table 1)

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In the ATP-binding pocket, the intermediate state had a conformation similar to that of the apo state, despite the drastic movement of the M-HEAT domain upon RHEB binding (Fig

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