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Furthermore, cannabis smoke alters the percentage of macrophage subpopulations within the lungs by increasing both tissue-resident and monocyte-derived alveolar macrophages as well as the IM1 subpopulation in male mice [140]

Phase 2 dose-ranging trials followed in 20042006, and the pivotal Phase 3 trials (studies LIPO-010-05 and LIPO-010-06) ran from 2006 to 2009 , forming the efficacy basis for the November 2010 FDA approval

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According to NICE Clinical Knowledge Summaries, B12 supplementation for confirmed deficiency should follow established protocols, but routine monitoring of B12 levels after treatment initiation is not always necessary unless clinical response is inadequate