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Targeted use (skin, detox): 5001,000 mg daily, split into two doses

The mean difference was found to be within the 95% confidence limits established by Bland and Altman, indicating a mean difference of 1.96 standard deviations

By targeting Nrf2, these phytochemicals enhance the skins endogenous defense mechanisms, reduce oxidative damage, and create a protective environment for melanocyte survival

PMID: 21447641 Sekhar RV, et al

Regulation of dual activity of ascorbate peroxidase 1 from Arabidopsis thaliana by conformational changes and posttranslational modifications

No dose above the clinically studied range (typically 250-1000mg) doesn't proportionally speed results and may increase side-effect risk instead