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Glutathione Deficiency in Cardiac Patients Is Related to the Functional Status and Structural Cardiac Abnormalities Lenzi A., et al (1992)

The lack of SLC7A11 in mice leads to a significant increase in plasma cysteine concentrations, and the survival of embryonic fibroblasts derived from these mice is compromised

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Following xenobiotic exposure, enzyme induction and its associated hepatocellular hypertrophy are not usually immediately apparent, with a maximal response occurring a few days to a week or more after exposure, since the enzyme inducer must first reach steady state, and new drug-metabolizing enzymes need to be synthesized

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