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Additionally, its counteracting effect occurred even with pre-existing adhesions ( Thus, with the damage of the peritoneum, two damaged peritoneal surfaces come into contact with each other, and the coagulation cascade is activated (Vukojevic et al., 2018

Nephrol Dial Transplant 29(Suppl 4):iv87-94

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Native IGF-1 is rapidly sequestered by IGF-binding proteins (IGFBPs) in the circulation, resulting in a half-life of approximately 1020 minutes