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Given that IBS symptoms can include diarrhoea, constipation, bloating, and pain, IBS patients are understandably concerned about how GLP-1 medications might influence their sensitive digestive systems
According to present invention, the fusion tag construct operably connected with insoluble tag and affinity tag
the coupling in the fragmental synthesis of the Lys 26 side chain in the preparation method is performed by condensing with DIC+A or B+A+C until the resin is detected to be transparent with ninhydrin, wherein A is chosen from HOBt or HOAt, B is chosen from HBTU, HATU, TBTU, PyAOP, or PyBOP, C is chosen from DIPEA or TMP
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Semaglutide is administered subcutaneously (under the skin) once a week using a pre-filled pen or syringe
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