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They are not FDA-approved (compounded medications are regulated differently), but they meet rigorous quality and potency requirements

Larson CM, Clohisy JC, Beaul PE, et al

21 Insulin binds the insulin receptor (INSR) on the plasma membrane of target cells, leading to the recruitment/phosphorylation of downstream proteins, that primarily including insulin receptor substrate (IRS), PI3-kinase(PI3K), and AKT isoforms, that are largely conserved among insulin target tissues and that initiate the insulin response

That can include muscle, water, glycogen, connective tissue, and other non-fat tissue

Tirzepatide is similar at about five days