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-Carotenes high lipophilicity (logP 7.7) underlies its extensive predicted volume of distribution (Vss 8.62 L/kg, Table 4), far exceeding doxorubicins more modest Vss 1.44 L/kg (Table 4)

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La conclusin fue clara: la capacidad del ALCAR de cruzar la barrera hematoenceflica y apoyar la sntesis de acetilcolina manteniendo al mismo tiempo la funcin de lanzadera mitocondrial perifrica lo convierte en la opcin con mayor alcance teraputico para este perfil

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