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Patients were identified through electronic medical records and used propensity score matching to compare them with a similar cohort of more than 385,000 patients who had never received GLP-1-RA therapy and did not have a prior AFib diagnosis

PLGA NPs have demonstrated minimal cytotoxic effects at concentrations up to 100 g/ml in both neuronal and glial cell cultures, and in vivo studies suggest lower accumulation in brain tissue and faster systemic clearance compared to metallic analogues [180]

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instead, they decrease neuronal survival