The vast majority of evidence comes from animal studies, which are promising but cannot be directly extrapolated to human outcomes
doi:10.1016/j.obpill.2025.100181 Veronese N, Solmi M, Caruso MG, et al
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Use caution when prescribing CONTRAVE to patients with an elevated risk of seizure, including: history of head trauma or prior seizure, severe stroke, arteriovenous malformation, central nervous system tumor or infection, or metabolic disorders (eg, hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia)
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