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Description

Enzyme purification experiments showed that Gdh1p and Gdh3p are hexamers (a6 50 kDa oligomeric structure) with the in vivo total NADP-GDH pool being a quite dynamic mixture of Gdh1p and Gdh3p monomers [15]

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Abnormalities in glutamate and GABA metabolic pathwaysincluding glutamatergic synapse, glutathione metabolism, GABAergic synapse, D-amino acid metabolism, arginine biosynthesis, alanine, aspartate, and glutamate metabolismwere observed in the top 20 (Figure 3C)

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also stated that MTX-induced oxidative stress may cause glomerular and tubular damage by causing MTX accumulation in the kidney (Reference Li, Abe and Yamakawa42)

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