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In addition, of the nine trials included in the sensitivity analysis of healthy individuals, three trials implemented a energy-restricted diet or exercise program in their intervention program

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Concurrently, total brain ferritin levels are decreased despite elevated ferritin deposition in the substantia nigra, where an increased ferritin heavy chain-to-light chain ratio is associated with reduced iron storage stability (Friedman and Galazka-Friedman, 2012)