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In the EMPA-REG study, empagliflozin significantly reduced the risk for the composite renal outcome, which included doubling of serum creatinine, progression of macroalbuminuria, initiation of renal replacement therapy, or renal death ( Subsequent studies, such as CREDENCE, DAPA-CKD, and EMPA-KIDNEY, were specifically designed to investigate the renoprotective effects of SGLT-2i

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Long-term success tends to correlate with adherence to dosing instructions, tolerance of dose escalation, and sustained lifestyle adjustments rather than willpower alone

10.1016/j.pharmthera.2021.107916 87 PettieJ

(Animal study)