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However, if antioxidant defense systems are severely impaired or the more realistic scenario that an iron supplement is co-ingested, the mode of cell death can be switched to ferroptosis

More detailed information about clinical trials of AKR1C3 were summarized in Table 2

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57,76 Moreover, in certain cell types, NADPH oxidase may translocate to the mitochondria, further exacerbating oxidative stress

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