doi: 10.1186/2040-2392-4-2
Under low oxygen conditions, HIF-1 acts as a key modulator of mitochondrial metabolism, actively repressing oxidative phosphorylation (OXPHOS) to reduce cellular oxygen consumption and mitochondrial-generated reactive oxygen species (ROS), which can be toxic at high levels (78)
Authors also thank Elisabeth Bascuana, Jordi Hernndez, Montserrat Jimnez, Damir Garcia-Cehic, Leonardo Nieto-Aponte, and Josep Gregori for their help in specimen processing
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Long-lasting remission of type 1 diabetes following treatment with topiramate for generalized seizures