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The transcriptional signatures identified in GLP-1MK-801-treated animals were enriched for functional terms related to synaptic transmission, such as postsynaptic density and glutamatergic synapse (Fig

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The following is a comparison of the incidence rates of gastrointestinal adverse events with semaglutide at different doses from randomized controlled trials: Serious events and warnings: Rare but serious side effects of semaglutide and dulaglutide are: Pancreatitis (inflammation of the pancreas) Changes in vision (worsening diabetic retinopathy) Gallbladder issues (cholecystitis and cholelithiasis) Injection site reactions (redness, inflammation, infection, and scarring) Severe stomachache Suicidal ideation Excessive burping Mood and behaviour changes Hypoglycemia Allergic or hypersensitivity reaction High risk of aspiration (stomach content entering the respiratory tract) during surgical procedures that require anesthesia or sedation GLP-1 medications are contraindicated for patients with a personal or family history of medullary thyroid carcinoma and MEN 2 syndrome (Multiple endocrine neoplasia type 2 syndrome)