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Once discussed mostly in specialty settings, they are now showing up in patient questions, provider consultations, regulatory discussions, and mainstream media coverage

doi: 10.1210/jc.2018-00408 49 Lillevang-JohansenMAbrahamsenBJrgensenHLBrixTHHegedsL

Disclosure The author declares that they do not have any financial involvement or affiliations with any organisation, association or entity directly or indirectly related to the subject matter or materials presented in this narrative review

While subcutaneous injection into the lower limbs may be possible, it is generally not recommended as a preferred injection site due to the possible complications involved including tissue damage and injection site reactions: The skin in the lower limbs is typically thinner and more sensitive than other parts of the body, which can increase the risk of pain, bleeding, and infection

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