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Adduction of Lys190, together with modification of additional residues, has been reported in later studies, after administration of AX in combination with clavulanic acid during more prolonged regimens, in higher doses or after intravenous administration (Garzon et al., 2014

While ertugliflozin did not outperform placebo for MACE, it significantly reduced hospitalizations for HF by 30% (59)

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