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The presence of m 5 C enhances base-stacking interactions and backbone rigidity, subtly increasing duplex stability by ~0.5 kcal/mol per modification ( 5 C levels have been linked to various diseases, including cancer, where they may contribute to tumorigenesis by altering the expression of oncogenes and tumor suppressor genes ( 2.1.1.3 N-Methyladenosine N-methyladenosine (mA) carries a positive charge at physiological pH because methylation at N quaternizes the ring nitrogen

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J Biol Chem 2005;280:31405-12

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Wetenschappers noemen het ook wel de 'koning van de antioxidanten'