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In BV2 microglial cell lines subjected to lipopolysaccharide (LPS)-induced neuroinflammation, both lactylation-mediated inhibition of p53 activity and direct knockdown of p53 protein can disrupt the control of the NF-B inflammatory signaling pathway, ultimately leading to abnormal expression of pro-inflammatory factors and M1 polarization of microglia [132]

To establish nude mouse xenograft tumor models, approximately 5 10 6 Cal27 cells per site were subcutaneously injected into the armpits of mice

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Caffeine, too, can raise cortisol levels and cause oxidative stress, meaning more glutathione is needed to combat it

& Dibner, C

Collectively, these results showed that NETosis is involved in lipofuscin-associated liver fibrosis