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In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)

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262 In addition, in solid organ transplant recipients (SOTr), low DKK-1 and increased secreted frizzled related protein-3 levels causing dysregulation of Wnt signalling were closely associated with cytomegalovirus (CMV) infection