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Innate Immun 24(4):221230 Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM et al (2011) CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

This vaccine has been used in adults and adolescents with a good safety profile

The corresponding fast infusion and high peak levels more likely approach the 5mg/kg suggested threshold for serotonin syndrome to occur

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More recently, reversible TPH inhibitors such as telotristat (Masib) derived from administration of the relatively inactive prodrug telotristat ethyl have been developed