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Free urate crystals have considerable pro-inflammatory potential, via the ability to activate synovial lining cells and leukocytes, to induce cleavage of C5 and subsequent activation of the membrane attack complex of complement, and to trigger certain other inflammatory cascades
doi: 10.1016/j.ccell.2017.02.013 35 JiangXLiuBNieZDuanLXiongQJinZet al
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Metabolic peptides (Tier 2 and 3) may be used for extended periods under medical supervision, with some patients transitioning to maintenance protocols once goals are achieved
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