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The clinical effect is best when timed to the natural GH pulse, but morning injection still produces clinical effects in patients who cannot inject at night

The observed effect is growth-mediated, not density-mediated

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Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC: Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily

Rather than acting as a systemic growth factor that elevates overall IGF-1 levels, MGF functions as an immediate, injury-responsive signal that helps trigger muscle adaptation at the site of stress

15-17 High-glycemic, refined carbohydrates also raise IGF-1 somewhat