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Though smFRET was demonstrated for the first time by Ha et al., in 1996 by obtaining simultaneous dual color images and emission spectra from donor and acceptor fluorophores linked by a short DNA molecule (Ha et al., 1996), the first actual application of this tool in analysis of IDPs was reported in 2007 by Mukhopadhyay et al., who demonstrated that the natively unfolded yeast prion protein adopts an ensemble of collapsed and rapidly fluctuating structures (Mukhopadhyay et al., 2007)

Studies in animal models of inflammatory bowel disease (IBD) demonstrate BPC-157 can reduce inflammation, promote mucosal healing, and protect against intestinal damage

Dev Cell 2015;32:3142

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Belvedere R, Novizio N, Morello S, Petrella A