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Clinically, non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of RA are achieved by inhibiting COX to inhibit the expression of PGE2

Ethics approval and consent to participate The medical ethics committee of the Maastricht University Medical Center+, the Netherlands approved the TearAD study (identifier: NL73600.068.20/METC 20033), and all participants provided written informed consent

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