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A lack of carnitine in dialysis patients is caused by insufficient carnitine synthesis and by the loss through dialytic membranes, leading, in some patients, to carnitine depletion and a concomitant relative increase in esterified forms of carnitine [43]

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These combinations are carefully tailored to optimize therapeutic outcomes based on individual health needs and goals

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In addition to containing high concentrations of polyunsaturated fatty acids and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage (Chance et al., 1979