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Phase 1 corresponds to a high level of activity in the primary afferent as a result of C-fiber activation due to peripheral stimulation, whereas phase 2 results from a continuous low-level small afferent input, together with a facilitated state of spinal processing [21]

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FIGURE 3 Another notable finding revealed by PET and NMR (nuclear magnetic resonance) spectroscopy analysis, is that in the brains of patients affected by ASD were found decreased glucose utilization and reduced ATP levels, further confirming mitochondrial dysfunction (Palmieri and Persico, 2010)

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