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However, individuals with very low body fat may benefit from gently pinching the skin to create a fold of subcutaneous tissue, ensuring the needle reaches fatty tissue rather than muscle

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The deal with the US biopharma adds a portfolio of clinical-stage incretin and amylin research programmes to its pipeline

Quality assessment The quality of the included studies was evaluated by the research design using appropriate instruments

Finally, the biology of non-response and therapeutic resistance - including the role of gut microbiome composition, adipose tissue dysfunction phenotypes, and genetic determinants of drug metabolism - represents a frontier for translational investigation to improve patient outcomes