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10.1016/j.jplph.2011.09.004 129 SunJ.GuJ.ZengJ.HanS.SongA

Mast cells release histamine and other inflammatory mediators, which may cause: Localized swelling Redness Itchiness Warmth This response is similar to what occurs with minor skin irritants or insect bites and is generally self-limiting

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Knee joint injuries The knee joint, as the most functionally and mechanically complex joint in the human body, is also the joint most susceptible to micro-injuries that lead to dysfunctions causing movement limitations, pain, and discomfort in the affected person

J Physiol Pharmacol 66:581590 Soares de Moura R, Rios AA, de Oliveira LF et al (2001) The effects of nitric oxide synthase inhibitors on the sedative effect of clonidine

Conditions like inflammatory bowel disease (IBD) have been shown to decrease production (16)