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Importantly, the metformin-mediated metabolic alterations demonstrated in rectal cancer in vitro , were also supported in vivo , with metformin demonstrated to significantly inhibit oxidative phosphorylation and glycolysis in treatment nave rectal cancer tissue biopsies

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In studies involving carbon tetrachloride (CCl4), a known hepatotoxin, hesperidin has demonstrated protective effects on the liver

10.1016/S0891-5849(99)00177-X

Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD